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KMID : 0356619930080040398
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Journal of Korean Society of Endocrinology
1993 Volume.8 No. 4 p.398 ~ p.403
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Clinical Usefulness of Urinary Growth Hormone Measurements in Adults
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정윤석
이현철/허갑범/김덕희/이명희
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Abstract
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ABSTRACT
@EN The evaluation of growth hormone (GH) secretion is an important problem in endocrine practice. The diagnosis of GH insufficiency is based on the finding of a blunted GH response to GH provocative tests or on the demonstration of a decreased
endogenous secretion. From a practical point of view, these methods are uncomfortable and complicated. Recently, very sensitive specific assays to measure human GH in urine have been developed.
We studied and compared measurements of urinary GH by two method including immunoradiometric assay (IRMA) and enzyme immunoassay (EIA). These commercially available assays allow measuring very low levels of GH in a small sample of untreated
urine.
Amounts of urinary GH measured by IRMA method were significantly correlated with serum insulin-like growth factor-1 levels and peak GH levels after L-dopa stimulation, whereas EIA method were not. Amounts of urinary GH were significantly lower in
aged
men than young men.
Therefore, the usefulness of urinary GH measurement is that of a simpler and cheaper screening method for assessing integrated serum GH concentration in clinical practice (J Kor Soc Endocrinol 8:398~403, 1993).
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KEYWORD
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